Photosynthetic bacteria-based cancer optotheranostics

Date:
February 16, 2021
Source:
Japan Advanced Institute of Science and Technology
Summary:
Natural purple photosynthetic bacteria (PPSB) can play a key role
as a highly active cancer immunotheranostics agent that uses the
bio-optical- window I and II near-infrared (NIR) light. PPSB have
high tumor specificity and non-pathogenicity. Active anticancer
efficacy and powerful multi-functions such as NIR-I-to-NIR-II
fluorescence, photothermal conversion, reactive oxygen species
generation, and contrasty photoacoustic effect, can be expressed
using NIR light exposure to PPSB.



FULL STORY ========================================================================== Cancer is one of the most thought-provoking healthcare problems throughout
the world. The development of therapeutic agents with highly selective anti-cancer activities is increasingly attractive due to the lack of
tumor selectivity of conventional treatments.


========================================================================== Scientists at Japan Advanced Institute of Science and Technology (JAIST)
have created a photosynthetic bacteria-based cancer optotheranostics.

Discovered by Associate Professor Eijiro Miyako and his team from
JAIST, natural purple photosynthetic bacteria (PPSB) can play a key
role as a highly active cancer immunotheranostics agent that uses the bio-optical-window I and II near-infrared (NIR) light thanks to the light harvesting nanocomplexes in microbial membrane. The NIR light-driven
PPSB would serve as an effective "all- in-one" theranostic material for
use in deep tumor treatments.

At least, the present work has the following great advantages in
comparison with other cancer treatments such as anticancer drug,
nanomedicine, antibody, and conventional microbial therapies.

1) PPSB have high tumor specificity and non-pathogenicity; 2) Sufficient
active cancer efficacy and multifunction such as NIR-I-to-NIR-II
fluorescence (FL), photothermal conversion, reactive oxygen species (ROS) generation, and contrasty photoacoustic (PA) effect, can be simultaneously expressed using NIR light exposure without chemical functionalizations and genetic manipulations; 3) Complicated and expensive procedures for their production are unnecessary because they can be spontaneously proliferated
by simple culturing in cheap medium.

The present experiments warrant further consideration of this novel
theranostic approach for the treatment of refractory cancers. The team
believes that the developed technology would advance cancer treatment
for creating more effective medicine.

The work was supported by the Japan Society for the Promotion of Science KAKENHI Grant-in-Aid for Scientific Research (A) and the KAKENHI Fund
for the Promotion of Joint International Research.

========================================================================== Story Source: Materials provided by Japan_Advanced_Institute_of_Science_and_Technology. Note: Content may
be edited for style and length.


========================================================================== Journal Reference:
1. Xi Yang, Satoru Komatsu, Sheethal Reghu, Eijiro Miyako. Optically
activatable photosynthetic bacteria-based highly tumor specific
immunotheranostics. Nano Today, 2021; 37: 101100 DOI: 10.1016/
j.nantod.2021.101100 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2021/02/210216094314.htm

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