More years of obesity means higher risk of disease, study finds

Date:
December 8, 2020
Source:
PLOS
Summary:
A greater obesity duration is associated with worse values for
all cardiometabolic disease factors, according to a new study.



FULL STORY ==========================================================================
A greater obesity duration is associated with worse values for all cardiometabolic disease factors, according to a new study published
this week in PLOS Medicine by Tom Norris of Loughborough University,
UK, and colleagues.


========================================================================== People with obesity do not all share the same risk for the development
of cardiometabolic disease risk factors. The duration a person has spent
with obesity over their lifetime has been hypothesized to affect this variation. In the new study, researchers used data from three British
birth cohort studies that collected information on body mass index from
age 10 to 40 as well as cardiometabolic disease risk factors -- blood
pressure, cholesterol and glycated hemoglobin (blood sugar) measurements
-- in 20,746 participants.

More years of obesity was associated with worse values for all measured cardiometabolic risk factors. The association was particularly strong
for glycated hemoglobin, or HbA1c; those with less than five years of
obesity had a 5% higher HbA1c (95%Confidence Interval 4-6) compared to
people with no years of obesity, while those with 20 to 30 years of
obesity had a 20% higher HbA1c (95%CI 17-23) compared to people with
no obesity. Importantly, this increased risk persisted when adjustment
was made for a robust measure of life course obesity severity. Other
measures of cardiometabolic disease risk (systolic and diastolic blood pressure, high density-lipoprotein cholesterol) were also associated with obesity duration, though these were largely attenuated when adjusting
for obesity severity.

"Our findings suggest that health policy recommendations aimed at
preventing early obesity onset, and therefore reducing lifetime exposure,
may help reduce risk of diabetes, independently of obesity severity,"
the authors say.


========================================================================== Story Source: Materials provided by PLOS. Note: Content may be edited
for style and length.


========================================================================== Journal Reference:
1. Tom Norris, Tim J. Cole, David Bann, Mark Hamer, Rebecca Hardy,
Leah Li,
Ken K. Ong, George B. Ploubidis, Russell Viner, William
Johnson. Duration of obesity exposure between ages 10 and 40
years and its relationship with cardiometabolic disease risk
factors: A cohort study. PLOS Medicine, Dec. 8, 2020; DOI:
10.1371/journal.pmed.1003387 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2020/12/201208142642.htm

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